Brandeis University

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Multiple Time-Scales Of Decision Making In Hippocampus And Prefrontal Cortex

Tang W*, Shin JD*, Jadhav SP (2021), “Multiple time-scales of decision making in the hippocampus and prefrontal cortex”, eLife, 10, e66227.  In this study, we establish neural population sequences at multiple timescales in the hippocampus and prefrontal cortex, and determine their complementary roles in memory-guided decision making. We demonstrate neural population sequences at multiple timescales in …

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Coordinated Hippocampal-Prefrontal Replay Supports Spatial Learning And Memory-Guided Decision Making

Shin JD*, Tang W*, Jadhav SP (2019), “Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making”, Neuron, 104(6), 1110-1125.  This study builds on previous findings about sharp-wave ripples (SWRs) and replay to show how coordinated brain activation in hippocampal-prefrontal circuits during awake replay supports spatial learning and memory-guided decision making. In awake replay, …

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Awake Sharp-Wave Ripple Replay Of Mental Experiences Critical For Learning

Jadhav SP, Kemere C, German PW, Frank LM (2012), “Awake hippocampal sharp-wave ripples support spatial memory”, Science, 336(6087): 1454-1458.  The hippocampus is essential for storing and retrieving daily memories, and the neurophysiological basis of memory is a key question. A major focus in the field has been the activity of place cells and its role in …

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