Research

Herzog LE, Katz DB, Jadhav SP (2020), “Refinement and reactivation of a taste-responsive hippocampal network”, Current Biology, 30, 1306-1311.  This study followed up on the discovery of a taste responsive hippocampal sub-network to examine changes in this network during novel taste experience. Our results showed that taste responsiveness is associated with initially larger spatially responsive place […]

Herzog LE, Pascual LM, Scott SJ, Mathieson ER, Katz DB, Jadhav SP (2019), “Interaction of taste and place coding in the hippocampus”, Journal of Neuroscience, 39(16), 3057-3069.  This study reported the discovery of taste-responsive place cells in the hippocampus. A subset of place cells with weak spatial responses discriminated between tastes based on palatability. The hippocampus

Jadhav SP*, Rothschild G*, Roumis DR, Frank LM (2016), “Coordinated excitation and inhibition of prefrontal ensembles during awake hippocampal sharp-wave ripple events”, Neuron, 90(1):113-27. doi: 10.1016/j.neuron.2016.02.010  This study showed that awake SWR replay during quiet waking states (when animals are inactive) corresponds to mental replay of ongoing spatial experiences. The hippocampus, the brain’s memory hub, communicates

Zielinski MC*, Shin JD*, Jadhav SP (2019), “Coherent coding of spatial position mediated by theta oscillations in the hippocampus and prefrontal cortex”, Journal of Neuroscience, 39(23), 4550-4565.  This study established that theta oscillations mediate a temporal coordination mechanism for coherent coding of spatial position in hippocampal-prefrontal networks during memory-guided behavior. We found that ensemble activity in the

Tang W, Shin JD, Frank LM, Jadhav SP (2017), “Hippocampal-prefrontal reactivation during learning is stronger in awake as compared to sleep states”, Journal of Neuroscience, 37(49): 11789-11805.  This study that revealed a surprising difference between awake and sleep replay. Despite the dogma that sleep replay is primarily responsible for reactivating memories of our experiences for permanent

Tang W*, Shin JD*, Jadhav SP (2021), “Multiple time-scales of decision making in the hippocampus and prefrontal cortex”, eLife, 10, e66227.  In this study, we establish neural population sequences at multiple timescales in the hippocampus and prefrontal cortex, and determine their complementary roles in memory-guided decision making. We demonstrate neural population sequences at multiple timescales in

Shin JD*, Tang W*, Jadhav SP (2019), “Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making”, Neuron, 104(6), 1110-1125.  This study builds on previous findings about sharp-wave ripples (SWRs) and replay to show how coordinated brain activation in hippocampal-prefrontal circuits during awake replay supports spatial learning and memory-guided decision making. In awake replay,

Jadhav SP, Kemere C, German PW, Frank LM (2012), “Awake hippocampal sharp-wave ripples support spatial memory”, Science, 336(6087): 1454-1458.  The hippocampus is essential for storing and retrieving daily memories, and the neurophysiological basis of memory is a key question. A major focus in the field has been the activity of place cells and its role in